November 22, 2025 4:07 PM EST

Carolina Panthers vs San Francisco 49ers 11/24/2025

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The San Francisco 49ers are a heavy favorite winning 77.0% of simulations over the Carolina Panthers. Brock Purdy is averaging 239.0 passing yards and 1.7 TDs per simulation and Christian McCaffrey is projected for 68.0 rushing yards and a 40.0% chance of having at least 1 rushing TD. In the 23.0% of simulations where Carolina Panthers wins, Bryce Young averages 1.8 TD passes vs 0.33 interceptions, while in losses he has a ratio of 1.09 TDs to 0.58 interceptions. Rico Dowdle averages 47.0 rushing yards and 0.21 rushing TDs when Carolina Panthers wins and 28.0 yards and 0.06 TDs in losses. San Francisco 49ers has a 67.0% chance of forcing more turnovers than they commit. Positive turnover margin helps them win 86.0% of the time.

CURRENT SEASON: We advise relying on these trends after the first 3 weeks of the season.

Carolina PanthersATS RECORDSan Francisco 49ersATS RECORDATS EDGE
All Games 7-4-0All Games 6-5-0No Edge
Road Games 40-20-00Home Games 1-3-0 No Edge
When Underdog 7-3-0When Favored 5-2-0No Edge
Non-Division Opp 5-3-0Non-Division Opp 3-3-0No Edge
Opp .500+ Record 4-1-0Opp .500+ Record 2-4-0No Edge

LAST SEASON: We advise factoring for these trends for the first 3 to 6 weeks of the Current Season.

Carolina PanthersATS RECORDSan Francisco 49ersATS RECORDATS EDGE
All Games 8-9-0All Games 5-12-0No Edge
Road Games 30-50-00Home Games 4-5-0 No Edge
When Underdog 8-8-0When Favored 5-8-0No Edge
Non-Division Opp 5-6-0Non-Division Opp 4-7-0No Edge
Opp Under .500 50-49-0Opp Under .500 39-53-0No Edge

OVER-UNDER TRENDS

Carolina PanthersO-U-P RECORDSan Francisco 49ersO-U-P RECORDO-U EDGE
All Totals (O-U-P) 6-5-0All Totals (O-U-P) 7-4-0OVER
On Road 3-3-0At Home 2-2-0No Edge
All Totals Last Season 13-4-0All Totals Last Season 11-6-0OVER
On Road Last Season 6-2-0At Home Last Season 5-4-0OVER

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