December 13, 2025 6:17 AM EST

Tennessee Titans vs San Francisco 49ers 12/14/2025

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The San Francisco 49ers are a solid favorite with a 72.0% chance to beat the Tennessee Titans. Christian McCaffrey is projected for 74.0 rushing yards and a 41.0% chance of having at least 1 rushing TD. In the 28.0% of simulations where Tennessee Titans wins, Cam Ward averages 1.71 TD passes vs 0.27 interceptions, while in losses he has a ratio of 1.07 TDs to 0.53 interceptions. Tony Pollard averages 47.0 rushing yards and 0.2 rushing TDs when Tennessee Titans wins and 33.0 yards and 0.06 TDs in losses. The San Francisco 49ers has a 48.0% chance of forcing more turnovers than they commit. Positive turnover margin helps them win 88.0% of the time.

CURRENT SEASON: We advise relying on these trends after the first 3 weeks of the season.

Tennessee TitansATS RECORDSan Francisco 49ersATS RECORDATS EDGE
All Games 6-7-0All Games 8-5-0No Edge
Road Games 30-30-00Home Games 2-3-0 No Edge
When Underdog 6-7-0When Favored 7-2-0No Edge
Non-Division Opp 5-3-0Non-Division Opp 5-3-0No Edge
Opp .500+ Record 3-5-0Opp Under .500 4-1-0No Edge

LAST SEASON: We advise factoring for these trends for the first 3 to 6 weeks of the Current Season.

Tennessee TitansATS RECORDSan Francisco 49ersATS RECORDATS EDGE
All Games 2-15-0All Games 5-12-0No Edge
Road Games 20-70-00Home Games 4-5-0 No Edge
When Underdog 2-10-0When Favored 5-8-0No Edge
Non-Division Opp 1-10-0Non-Division Opp 4-7-0No Edge
Opp Under .500 12-93-0Opp Under .500 39-53-0No Edge

OVER-UNDER TRENDS

Tennessee TitansO-U-P RECORDSan Francisco 49ersO-U-P RECORDO-U EDGE
All Totals (O-U-P) 8-5-0All Totals (O-U-P) 7-5-1OVER
On Road 3-3-0At Home 2-3-0UNDER
All Totals Last Season 10-6-1All Totals Last Season 11-6-0OVER
On Road Last Season 7-2-0At Home Last Season 5-4-0OVER

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