September 17, 2025 4:31 AM EST

Arizona Cardinals vs San Francisco 49ers 09/21/2025

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Expect a close game with the Arizona Cardinals winning 55.0% of simulations, and the San Francisco 49ers 45.0% of simulations. In close games, turnover margin is especially important. The Arizona Cardinals commit fewer turnovers in 52.0% of simulations and they go on to win 73.0% when they take care of the ball. The San Francisco 49ers wins 67.0% of the simulations in which they commit fewer turnovers. James Conner is averaging 69.0 rushing yards per sim. If he can have a great game with better than average rushing yards and at least a 1 rushing TD (27.0% chance) then he helps his team win 77%. Christian McCaffrey is averaging 55.0 rushing yards per sim. If he can have a great game with better than average rushing yards and at least a 1 rushing TD (30.0% chance) then he helps his team win 66%.

CURRENT SEASON: We advise relying on these trends after the first 3 weeks of the season.

Arizona CardinalsATS RECORDSan Francisco 49ersATS RECORDATS EDGE
All Games 1-1-0All Games 2-0-0San Francisco 49ers
Road Games 10-00-00Home Games 0-0-0 No Edge
When Underdog 0-0-0When Favored 2-0-0No Edge
Division Opp 0-0-0Division Opp 1-0-0No Edge
Opp .500+ Record 0-0-0Opp .500+ Record 0-0-0No Edge

LAST SEASON: We advise factoring for these trends for the first 3 to 6 weeks of the Current Season.

Arizona CardinalsATS RECORDSan Francisco 49ersATS RECORDATS EDGE
All Games 10-6-1All Games 5-12-0No Edge
Road Games 40-30-10Home Games 4-5-0 No Edge
When Underdog 6-2-1When Favored 5-8-0No Edge
Division Opp 4-2-0Division Opp 1-5-0No Edge
Opp Under .500 73-20-0Opp Under .500 39-53-0No Edge

OVER-UNDER TRENDS

Arizona CardinalsO-U-P RECORDSan Francisco 49ersO-U-P RECORDO-U EDGE
All Totals (O-U-P) 1-1-0All Totals (O-U-P) 1-1-0No Edge
On Road 0-1-0At Home 0-0-0UNDER
All Totals Last Season 9-7-1All Totals Last Season 11-6-0OVER
On Road Last Season 4-3-1At Home Last Season 5-4-0OVER

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